Keywords: Alzheimer's Disease, Alzheimer's Disease
Motivation: Tau deposition is an important pathological process in aging and AD/MCI.
Goal(s): Analyze oxygen metabolism and association with Tau burden.
Approach: We mapped CMRO2 with ASL based CBF and mGRE based OEF in an AD cohort. We compared the spatial distribution and association with Tau burden measured with 18F-MK-6240 PET.
Results: We found that a higher Tau deposition is associated with lower CMRO2 at both subject and regional levels, especially in cortical temporal and parietal lobes. Oxygen metabolism measured with MRI is a potential biomarker in aging and AD and opens opportunities for future research of tau accumulation and metabolism dysfunction.
Impact: Negative association observed between tau deposition and oxygen metabolism at both subject and regional levels extend understanding of the neurotoxity of tau accumulation, potentially helps to the development of tau targeted disease modifiers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords