Abstract #1787

Determinants of Cognitive and Brain Resilience to Reduced Neuronal Metabolism in Alzheimer’s Disease: A Longitudinal Whole-Brain MRSI Study

Wenli Li¹, Miao Zhang², Yibo Zhao³, Yudu Li^3,4,5, Wen Jin^3,6, Yaoyu Zhang¹, Jialin Hu¹, Zhi-Pei Liang^3,6, and Yao Li^1,7

¹National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁷Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: The role of demographic and genetic factors in the relationship between neuronal metabolism and cognitive/brain resilience in AD is unclear.

Goal(s): To identify factors (age, sex, APOE-ε4, education, and brain atrophy) that contribute to preserved cognition and brain structure despite reduced neuronal metabolism.

Approach: We studied 150 participants (41 with MCI, 109 with AD), 27 with follow-ups, all undergoing whole-brain ¹H-MRSI and cognitive assessments. Moderation effects of these factors on neuronal metabolism, cognitive decline, and cortical thinning were analyzed.

Results: Education and brain volume moderated the impact of impaired neuronal metabolism on cognitive decline, with education enhancing brain resilience.

Impact: Education and brain volume moderated the impact of impaired neuronal metabolism on cognitive decline, with education also moderated the effect on brain resilience. These findings suggest that education may be protective against cognitive decline and brain atrophy despite neuronal dysfunction.

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