Abstract #1788

Impaired Glucose Metabolism Detected In Six-month-old 5xFAD Mice Using Deuterium MRI

Ganghan Yang^1,2, Qian Wan¹, Lixian Zou¹, Hao Peng¹, Liwen Wan³, Zhaoyang Xu¹, Ye Li¹, and Xin Liu¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²College of Engineering, Southern University of Science and Technology, shenzhen, China, ³Research Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, deuterium

Motivation: Impaired brain energy metabolism at early stage is found to be the driving factor of AD progression.

Goal(s): To investigate the potential of using deuterium MRI to detect alterations in brain energy metabolism in 5xFAD mice before the onset of significant cognitive symptoms.

Approach: Deuterium MRI was performed at 11.7T following a tail vein injection of [2, 3, 4, 6, 6'-²H₅]-glucose (3 g/kg). Behavior test, PET-MRI, histology and immunostaining were performed.

Results: The averaged normalized ²H-Glx signal in 5xFAD mice was observed to be higher than in wild-type mice at about 100min after the glucose administration.

Impact: This study demonstrates the potential of deuterium MRI to detect early alterations in brain energy metabolism. Noninvasive evaluation of oxidative metabolism may provide valuable perspective of AD progression, which can help to identify potential interventions to slow its progression.

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