Abstract #1789

Mapping Brain Tissue Sodium Concentration in Cognitively Unimpaired Elderly Subjects: a 7T Sodium MRI study

Alexa Haeger^1,2, Sandro Romanzetti^1,2, Fawzi Boumezbeur³, Julien Lagarde^4,5, Marie Sarazin^4,5, Jörg B. Schulz^1,2, Kathrin Reetz^1,2, and Michel Bottlaender^3,4

¹Neurology, RWTH University Hospital, Aachen, Germany, ²JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany, ³NeuroSpin, Joliot Life Sciences Institute, CEA, Paris-Saclay University, Gif-Sur-Yvette, France, ⁴Université Paris Saclay, BioMaps, CEA, Orsay, France, ⁵Neurologie de la mémoire et du language, GHU-Paris Psychiatrie Neurosciences, Paris, France

Synopsis

Keywords: Aging, Aging

Motivation: ²³Na-MRI is an imaging technique to visualize cerebral sodium concentrations, serving as a potential estimate of brain metabolic state.

Goal(s): To establish a map of normal brain tissue sodium concentration in cognitively unimpaired elderly subjects and its relation with age.

Approach: ²³Na-MRI acquisition on a ultra-high field 7T in a cohort of 80 healthy elderly subjects (50-80 years old).

Results: Quantification parametric maps of tissue sodium concentration under ultra-high-field MRI conditions were created in elderly subjects and no strong association with age was found.

Impact: 23Na-MRI imaging may be a sensitive tool to discriminate between physiological cerebral aging and decline during pathological processes.

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