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Abstract #1790

Investigation of Iron Deposition Metabolism in Alzheimer’s Disease in Hippocampal Subregions using QSM-MRI

Dongxue Li1,2, Junjie He2, Lin Zhu2, Yuezong Yang1,2, Lisha Nie3, and Rongpin Wang2
1Medical College, Guizhou University, Guiyang, China, 2Department of Radiology, Guizhou International Science & Technology Cooperation Base of Precision Imaging for Diagnosis and Treatment, Guizhou Provincial People’s Hospital, Guiyang, China, 3GE HealthCare MR Research, Beijing, China

Synopsis

Keywords: Alzheimer's Disease, Head & Neck/ENT, Quantitative Susceptibility Mapping, Hippocampal Subregions

Motivation: Iron accumulation and ferroptosis are implicated in Alzheimer’s disease (AD), but their impact on neuronal volume in hippocampal subregions remains unclear.

Goal(s): To examine the association between iron deposition and neuronal volume in AD hippocampal subregions, identifying imaging biomarkers.

Approach: Using QSM and 3D T1-weighted MRI, we quantified magnetic susceptibility and volume in 24 hippocampal subregions segmented by FreeSurfer.

Results: QSM and 3D T1WI identified several abnormal hippocampal regions of interest, which were sensitive to tissue alterations. Increased iron deposition in certain hippocampal subregions was accompanied by a reduction in volume.

Impact: The reduction in volume (neuronal loss) coupled with increased iron deposition in specific subregions offers insights into the mechanisms of neuronal ferroptosis and serves as a reference for personalized treatment strategies.

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