Meeting Banner
Abstract #1791

Age and sex-related changes of the GSH level of the striatum in healthy individuals as revealed with proton magnetic resonance spectroscopy

Youmin Zhang1,2, Naying He1, Peng Wu3, JinYuan Weng3, and Fuhua Yan1,2
1Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, 2College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Philips Healthcare, Shanghai, China, Shanghai, China

Synopsis

Keywords: Aging, Aging

Motivation: The glutathione (GSH) depletion and/or alterations in its metabolism in the brain are closely related to neurodegeneration diseases especially the pathogenesis of Parkinson’s disease.

Goal(s): To characterize the effect of age and sex on the GSH in striatum in normal controls.

Approach: Taking advantage of proton magnetic resonance spectroscopy (1H-MRS) with MEscher-Garwood Point RESolved Spectroscopy (MEGA-PRESS) to detect GSH levels in specific brain regions.

Results: In healthy populations (age range: 21-77 years), GSH levels in the left striatum showed a negative correlation with age.

Impact: This study offered a baseline of GSH level in the striatum which provided a reference for further research regarding the degree of oxidative stress.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords