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Abstract #1798

3D EPI Performance in Detecting Microhemorrhage, Compared to 2D GRE

Ian Langenfeld1, Dan Rettmann2, Brice Fernandez3, Tim Sprenger4, Suchandrima Banerjee5, Steven Messina6, and Petrice Cogswell6
1MRI, GE HealthCare, ROCHESTER, MN, United States, 2GE HealthCare, ROCHESTER, MN, United States, 3GE HealthCare, Buc, France, 4GE HealthCare, Munich, Germany, 5GE HealthCare, Menlo Park, CA, United States, 6Radiology, Mayo Clinic, ROCHESTER, MN, United States

Synopsis

Keywords: Alzheimer's Disease, Degenerative

Motivation: Improve detection sensitivity while maintaining reasonable scan times.

Goal(s): Assess how the newly available, 3D Echo Planar Imaging (EPI), performs when compared to 2D GRE in detection of cerebral microhemorrhages (mH).

Approach: Conducted on 15 patients with confirmed mHs, and independently reviewed the 2D GRE and 3D EPI images to assess the number and distribution of definite mH and possible mH.

Results: 3D EPI sequence allowed the detection of 26 definite and 3 possible mHs, compared to 17 definite and 8 possible mHs identified by the 2D GRE sequence. 3D EPI was comparable to 2D GRE at approximately 1 minute of scan time.

Impact: The introduction of 3D EPI as a fast, highly sensitive pulse sequence for detecting microhemorrhages could aid in MRI-based diagnosis in neurodegenerative diseases.

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