Keywords: Biomarkers, Hyperpolarized MR (Non-Gas), Gluconeogenesis, Fumarase, PEPCK, PDH
Motivation: Clinical diagnosis and management of acute kidney injury rely on systemic blood biomarkers, lacking specificity and sensitivity of associated renal metabolism.
Goal(s): To examine changes of renal oxidative and gluconeogenic metabolism induced by acute kidney injury.
Approach: Hyperpolarized (HP) [1-13C]pyruvate and HP [1,4-13C2]fumarate were separately used to assess pyruvate dehydrogenase (PDH) and phosphoenolpyruvate carboxykinase (PEPCK) activities in rat kidneys with unilateral ischemia reperfusion injury.
Results: [13C]Bicarbonate produced from HP [1-13C]pyruvate and HP [1,4-13C2]fumarate decreased, suggesting suppressed PDH flux and gluconeogenic pathway, respectively.
Impact: The proposed imaging methods and biomarkers can be broadly applicable to other types of tissue injuries, as well as renal or hepatic diseases that affect metabolism.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords