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Abstract #1814

EPR oximetry with Ox071 detects renal hypoxia in cisplatin-induced chronic kidney disease models

Kazumasa Horie1, Shun Kishimoto1, Manabu Horikawa1, Norikazu Koyasu1, Kazutoshi Yamamoto1, Jeffrey Robert Brender1, Nallathamby Devasahayam1, and Murali Krishna Cherukuri1
1NCI, Bethesda, MD, United States

Synopsis

Keywords: Preclinical Image Analysis, Electron Paramagnetic Resonance

Motivation: EPR oximetry using Ox071 holds promise in detecting chemotherapy-induced chronic kidney injury by monitoring pO2 distribution.

Goal(s): Using EPR, our study assessed the ability to discern pO2 variations between healthy kidneys and kidney injury models induced by intraperitoneal cisplatin treatment.

Approach: To validate these changes, we performed longitudinal EPR-based pO2 imaging.

Results: The analysis of EPR oximetry results consistently showed renal hypoxia two months after treatment, which aligns with kidney fibrosis confirmed by the ex vivo protein assay.

Impact: Traditionally, EPR oximetry has concentrated on tumor hypoxia due to Ox063’s limitations in well-oxygenated tissues. Using Ox071, a deuterated analog, this research broadens the application of oximetry to kidneys, where hypoxic changes serve as a critical indicator of fibrosis.

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