Keywords: Lung, Low-Field MRI, Respiratory motion resolved; Deep Image Prior
Motivation: Quantitative mapping may enable early detection/monitoring of pulmonary diseases, with free-breathing imaging essential for patients with compromised lung capacity.
Goal(s): This work aims to develop free-breathing 2D lung MR Fingerprinting T1, T2, and M0 mapping at 0.55T with respiratory self-navigation.
Approach: Data were acquired in three healthy subjects using a 30-second free-breathing MRF sequence at 0.55T with respiratory self-navigation Respiratory motion-resolved maps were obtained using a Deep Image Prior reconstruction.
Results: Free-breathing 0.55T lung MRF was successful in all subjects, yielding average values of 645±123ms (inspiration) and 638±129ms (expiration) for T1, and 42±2ms (inspiration), and 44±2ms (expiration) for T2.
Impact: This work demonstrates feasibility of free-breathing lung MR Fingerprinting for respiratory motion-resolved 2D T1, T2 and M0 mapping at 0.55T in healthy subjects, which may have potential clinical applications to pulmonary conditions, such as emphysema, COPD, and interstitial lung diseases.
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