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Abstract #1906

Model-free parameters of IVIM combined with tumor aggressiveness indicators in predicting 5-year treatment outcome in NPC

Fan Yang1, Haoran Wei1, Xiaoduo Yu1, Lizhi Xie2, Meng Lin1, and Hongmei Zhang1
1Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China, Beijing, China, 2GE Healthcare, Beijing, China

Synopsis

Keywords: Head & Neck/ENT, Head & Neck/ENT, Nasopharyngeal carcinoma; Tumor aggressiveness; virtual magnetic resonance elastography; signature index; prognosis

Motivation: The postprocessing of IVIM is relatively laborious within multiple b-value settings. Streamlining the b-value configuration and postprocessing may promote its widespread use while ensuring the clinical efficacy.

Goal(s): To assess the value of model-free parameters (virtual magnetic resonance elastography [vMRE] and signature-index [S-index]) of IVIM and tumor aggressiveness indicators (tumor growth type [TGT] and contralateral pharyngeal recess invasion [CPRI]) in predicting 5-year treatment outcome.

Approach: Prospective inclusion of 106 patients with regular follow-up. Selection of appropriate statistical methods to construct models.

Results: vMRE and S-index were the independent predictors of long-term survival. Combined with TGT and CPRI can further improved the predictive performance.

Impact: Two model-free parameters simplified the clinical process without compromising the efficacy. vMRE/S-index and TGT/CPRI shown for the first time to predict long-term survival in NPC, helping with clinical treatment decisions.

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