Keywords: Head & Neck/ENT, Head & Neck/ENT, nasopharyngeal carcinoma, synthetic magnetic resonance imaging, chemoradiotherapy response
Motivation: About 10%~30% of advanced nasopharyngeal carcinoma (ANPC) remained residual and relapse after chemoradiotherapy (CRT), so it would be valuable to pretreatment prediction of no-response ANPC.
Goal(s): Quantitative syMRI parameters for predicting no-response ANPC before CRT.
Approach: 95 response and 32 no-response ANPC were enrolled, and the T1, T2, PD values from syMRI and clinicopathological characteristics were compared. Logistic regression was used to construct prediction model.
Results: T1, T2, PD values were significantly lower in no-response ANPC. The combination of T1, T2, PD can achieve good prediction performance (AUC=0.897). The syMRI combined with clinicopathological characteristics can improve prediction performance (AUC=0.974).
Impact: Our study suggested syMRI can non-invasively identify no-response ANPC patients before CRT. Therefore, the application of syMRI would be beneficial for treatment selection and management of ANPC patients.
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