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Abstract #1935

In Vivo Imaging of Xenon Biosensors using Hyperpolarized 129Xe MRI

Ming Zhang1,2, Haidong Li1,2, Hongchuang Li1,2, Xiuchao Zhao1,2, Qingbin Zeng1,2, Weiping Jiang1,2, Yaping Yuan1,2, Xiaoling Liu1,2, Yu Zheng1, Sen Yue1,2, Qianni Guo1,2, Yeqing Han1,2, Xin Lou3, Louis-S Bouchard4, and Xin Zhou1,2,5
1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China, 2University of Chinese Academy of Sciences, Beijing, China, 3Department of Radiology, Chinese PLA General Hospital, Beijing, China, 4Jonsson Comprehensive Cancer Center, The Molecular Biology Institute, California NanoSystems Institute, Departments of Chemistry and Biochemistry, University of California, Los Angeles, CA, United States, 5School of Biomedical Engineering, Hainan University, Haikou, China

Synopsis

Keywords: Probes & Targets, Hyperpolarized MR (Gas), Xenon biosensors; In vivo; Glioma

Motivation: Molecular MRI based on hyperpolarized xenon biosensors is a promising approach for detecting biological processes due to its superior signal and chemical shift sensitivity. However, in vivo applications remain challenging.

Goal(s): To investigate the distribution and dynamics of xenon biosensors in vivo.

Approach: A robust method was developed for direct imaging of 129Xe in cage molecules. The decay time constant (Tdecay) and exchange time constant (Tex) of the caged 129Xe were measured in vivo.

Results: Caged 129Xe was accurately imaged. Moreover, significant differences were found in Tdecay across different brain regions and in Tex between glioma-bearing rats and controls.

Impact: Our findings advance molecular MRI technology by improving understanding of xenon biosensor distribution and dynamics. This approach lays the groundwork for future clinical applications of hyperpolarized xenon biosensors.

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Abstract

Keywords