Keywords: Probes & Targets, Head & Neck/ENT
Motivation: Early detection of malignant transformation in oral potentially malignant disorders (OPMDs) is challenging.
Goal(s): This study evaluates a MET-targeted near-infrared fluorescence imaging (NIRFI) probe, cMBP-ICG, to improve biopsy site accuracy in OPMDs.
Approach: Using preclinical models and a clinical trial with 50 patients, NIRFI-assisted biopsy was compared to conventional methods.
Results: Results showed NIRFI achieved 100% sensitivity and 86% specificity in detecting high-grade dysplasia and early malignancies, outperforming traditional biopsy accuracy (91% vs. 72%). These findings indicate that NIRFI has potential to enhance diagnostic precision and support earlier intervention for patients at risk of oral cancer.
Impact: This study highlights NIRFI-assisted biopsy as a promising tool for enhancing early detection in oral cancer risk. By improving diagnostic precision in OPMDs, it opens avenues for research into broader applications of NIRFI in other head and neck cancers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords