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Abstract #1942

Radical-Free Hyperpolarized α-Ketoglutarate: Non-persistent radicals for Dissolution DNP

Adam P Gaunt1, Jennifer S Lewis2, William J Byrne3, Yaewon J Kim2, Xiao J Ji2, Daniel B Vigneron2, Arnaud B Comment4, and Jeremy W Gordon2
1GE Healthcare, San Francisco, CA, United States, 2Radiology, UCSF, San Francisco, CA, United States, 3UCSF, San Francisco, CA, United States, 4GE Healthcare, Cambridge, United Kingdom

Synopsis

Keywords: Probes & Targets, Hyperpolarized MR (Non-Gas), non-persistent radical

Motivation: Hyperpolarized (HP) 13C-α-Ketoglutarate (αKG) can be used for assessing the metabolic profile of low-grade glioma, a deadly condition requiring improved diagnostic methods.

Goal(s): To demonstrate the utility of HP photo-irradiated 13C-αKG as a metabolic imaging 13C-probe.

Approach: High concentration 13C-αKG, irradiated with UV light followed by solid-state DNP at 6.7T and 1.4K, and liquid-state HP measurements.

Results: UV-induced radical build-up of 1 mM/s. Solid-state polarization of 45+10% (equivalent to optimized pyruvate/trityl sample), 4-fold signal increase from microwave frequency modulation, dissolution DNP and liquid-state polarization of 16+5% (at the point of measurement).

Impact: HP photo-irradiated 13C-αKG can provide valuable metabolic information for assessing low-grade glioma1, potentially leading to improved diagnostic and treatment evaluation methods.

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Keywords