Keywords: Probes & Targets, Hyperpolarized MR (Non-Gas), non-persistent radical
Motivation: Hyperpolarized (HP) 13C-α-Ketoglutarate (αKG) can be used for assessing the metabolic profile of low-grade glioma, a deadly condition requiring improved diagnostic methods.
Goal(s): To demonstrate the utility of HP photo-irradiated 13C-αKG as a metabolic imaging 13C-probe.
Approach: High concentration 13C-αKG, irradiated with UV light followed by solid-state DNP at 6.7T and 1.4K, and liquid-state HP measurements.
Results: UV-induced radical build-up of 1 mM/s. Solid-state polarization of 45+10% (equivalent to optimized pyruvate/trityl sample), 4-fold signal increase from microwave frequency modulation, dissolution DNP and liquid-state polarization of 16+5% (at the point of measurement).
Impact: HP photo-irradiated 13C-αKG can provide valuable metabolic information for assessing low-grade glioma1, potentially leading to improved diagnostic and treatment evaluation methods.
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