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Abstract #1946

Quantitative MRI Oximetry: Combining EPR and OE-MRI for Volumetric Mapping of Hypoxia in Tumors

Conner S. Ubert1, Victor B. Kassey1, Maciej M. Kmiec1, and Periannan Kuppusamy1
1Dartmouth College, Hanover, NH, United States

Synopsis

Keywords: Biomarkers, Quantitative Imaging, EPR, Hypoxia, OE-MRI

Motivation: This study is driven by the need for a reliable method to correlate R1 maps from Oxygen-Enhanced MRI (OE-MRI) with absolute hypoxia levels in tumors, to improve outcomes in MR-guided radiation treatment.

Goal(s): The aim is utilize electron paramagnetic resonance (EPR) Oximetry to develop a calibration curve between R1 and pO2.

Approach: Using a solid tumor model with two implanted EPR probes, OE-MRI was conducted at 21% and 100% oxygen to gather data for calibration.

Results: The correlation between OE-MRI R1 data and EPR Oximetry provided a viable hypoxia map, which could be used to increase the efficacy of MR-guided radiation therapy.

Impact: This study investigates a calibration method, which could act as a quality assessment tool for the hypoxia maps generated using OE-MRI, potentially improving personalized cancer treatments.

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