Abstract #1955

Resting-state fMRI analyses of a pain state transition induced by a chemokine signal-regulating agent in tumor model mice

Sosuke Yoshinaga¹, Takuto Shinjo¹, Yuki Kawachi¹, Yuya Terashima², Etsuko Toda³, Kouji Matsushima², Tomokazu Tsurugizawa⁴, and Hiroaki Terasawa¹

¹Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ²Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan, ³Nippon Medical School, Tokyo, Japan, ⁴National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

Synopsis

Keywords: Small Animals, fMRI (resting state), Cancer pain, Drug discovery

Motivation: Chronic pain significantly interferes with daily life in cancer patients. However, the mechanisms of pain responses and neurotransmission circuits in the brain remain elusive.

Goal(s): The aim is to develop a diagnostic MRI method to monitor the cancer pain state and the state transition induced by analgesic candidates.

Approach: Tumor-bearing cancer pain model mice were monitored by resting-state fMRI, and the pharmacological effect was evaluated for a newly developed chemokine signal-regulating agent.

Results: Pain-related brain regions were significantly identified in stronger functional connective networks, while functional connectivity was suppressed after administration of the chemokine signal-regulating agent.

Impact: The pain state transition induced by the analgesic agent in the tumor-bearing mouse brain was characterized by resting-state fMRI. Our experimental system is useful for the evaluation of new analgesic candidates in nonclinical and, expectantly, clinical studies.

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