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Abstract #2008

Simultaneous measurement of water, MT, CEST, myelin water fraction, and susceptibility contrast using rosette-accelerated MR fingerprinting

Sultan Zaman Mahmud1 and Hye-Young Heo1
1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: Quantitative MR-derived tissue parameters are typically measured one by one, which is time-consuming for clinical practice.

Goal(s): To develop a novel multi-parametric MR fingerprinting (MRF) framework that simultaneously measures water, semisolid MT, CEST, myelin water fraction (MWF), and susceptibility contrast in a single scan.

Approach: A motion-robust, rosette-accelerated MRF sequence was developed by combining RF saturation and T2-preparation modules. Optimized MRF acquisition parameters including RF saturation strength, saturation duration, frequency offset, relaxation delay, T2-prep TE, and readout TE, were varied during acquisition.

Results: The multi-parametric rosette-MRF technique accurately quantified water, semisolid MT, CEST, MWF, susceptibility contrast, and B0 inhomogeneity from a single scan.

Impact: A rosette-accelerated, multi-parametric MRF technique efficiently assesses various tissue parameters that serve as candidate biomarkers, providing valuable insights into a range of pathologies.

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Keywords