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Abstract #2011

Orientation-independent magnetization transfer measurement of white matter in brain

Zijian Gao1, Ziqin Zhou1,2, Ziqiang Yu1, Jian Hou1, Qianxue Shan1, and Weitian Chen1
1Department of Imaging and Interventional Radiology, The Chinese Univeristy of Hong Kong, Hong Kong, Hong Kong, 2MR Research Collaboration, Siemens Healthineers Ltd, Hong Kong, Hong Kong

Synopsis

Keywords: Magnetization Transfer, CEST & MT, Macromolecular proton fraction; Orientation independence; Quantitative imaging

Motivation: Quantitative magnetization transfer (MT) imaging of white matter in human brain exhibits orientation dependence, potentially confounding its clinical application.

Goal(s): This study demonstrates that Macromolecular Proton Fraction Mapping based on Spin-Lock (MPF-SL) has significantly reduced orientation sensitivity than saturation-pulse based MT imaging in the human brain.

Approach: Two healthy human volunteers underwent MRI exams at two different head orientations, including MPF-SL, saturation-pulse based MT imaging and diffusion tensor imaging (DTI). The DTI was performed to determine the orientation of white matter fiber with respect to static magnetic field B0.

Results: The MPF-SL technique yields significantly reduced orientation sensitivity than saturation-pulse based approach.

Impact: The MPF-SL technique provides a potential solution for orientation-independent magnetization transfer measurement of white matter in human brain.

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