Meeting Banner
Abstract #2017

Investigating ihMT T1D-filtering imaging for characterizing demyelination and inflammation processes in MS lesions

Guillaume Duhamel1,2, Timothy Anderson1,2, Andreea Hertanu1,2, Lucas Soustelle1,2, Ludovic de Rochefort1,2, Lauriane Pini1,2, Gopal Varma3, David C. Alsop3, Jean Pelletier4, and Olivier M. Girard1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Havard Medical School, Boston, MA, United States, 4APHM, Hôpital Universitaire Timone, Service de neurologie, Marseille, France

Synopsis

Keywords: Magnetization Transfer, biomarkers

Motivation: Pathological processes following MS lesion formation (demyelination and inflammation) need to be better characterized.

Goal(s): Investigating ihMT T1D filters as semi-quantitative markers of demyelination and inflammation in MS lesions.

Approach: The relation between ihMT T1D filters and the density of myelin [My] and other motion-restricted macromolecules (e.g., macrophages) [Mm] was exploited to derive [My] and [Mm] images in MS patients and evaluate their intensity in MS lesions.

Results: Various levels of demyelination and macromolecular density were revealed by [My] and [Mm] signals in lesions. A mismatch between [Mm] and QSM may indicate a sensitivity of ihMT T1D filters to different ranges of macromolecules.

Impact: Semi-quantitative measures of the density of myelin and that of other macromolecules can be obtained with a single MR experiment using ihMT T1D filtering. This technique might be used to characterize demyelination and processes of inflammation in MS lesions.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords