Abstract #2018

The role of incidental magnetization transfer in divided subtracted inversion recovery

Mark Bydder¹, Tracy R Melzer ^2,3,4, Nickolas J Palmer⁵, Paul Condron^1,6, Daniel M Cornfeld^1,6, Eryn Kwon ^1,7, Maryam Tayebi ^1,7, Gil Newburn ¹, Miriam Scadeng ^6,7, Samantha J Holdsworth ^1,6, and Graeme M Bydder^1,8

¹Mātai Medical Research Institute, Gisborne, New Zealand, ²University of Otago, Christchurch, New Zealand, ³New Zealand Brain Research Institute, Christchurch, New Zealand, ⁴University of Canterbury, Christchurch, New Zealand, ⁵Pacific Radiology Canterbury, Christchurch, New Zealand, ⁶The University of Auckland, Auckland, New Zealand, ⁷Auckland Bioengineering Institute, Auckland, New Zealand, ⁸University of California San Diego, San Diego, CA, United States

Synopsis

Keywords: Magnetization Transfer, Neuroinflammation

Motivation: The dSIR sequence shows changes in mTBI patients that have not been seen previously that correspond to a small difference in T₁. The motivation of the study is to understand the origin of the signal changes.

Goal(s): The goal is to examine the effect of incidental magnetization on the dSIR signal in normal subjects and patients with mTBI.

Approach: This is an in vivo clinical study using sequence parameters to vary the incidental magnetization transfer.

Results: Results showed that normal white matter exhibited a strong dSIR signal (T₁) reduction in response to MT irradiation whereas a patient with mTBI did not.

Impact: This study identifies a plausible mechanism for dSIR signal changes in white matter that may lead to more efficient methods of detecting mTBI and hypoxic injuries.

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