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Abstract #2019

Reducing ihMT acquisition time using alternating single frequency MT preparation and variable flip angle readouts

Gopal Varma1, Aaron K Grant1, Lucas Soustelle2, Olivier M Girard2, Guillaume Duhamel2, and David C Alsop1
1Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Aix Marseille Univ, CNRS, CRMBM, Marseille, France

Synopsis

Keywords: Magnetization Transfer, Magnetization transfer, ihMT

Motivation: IhMT demonstrates unique specificity and sensitivity to myelin. However, clinical translation of ihMT is hindered by the acquisition time.

Goal(s): Reduce ihMT acquisition times by: exploiting dipolar order decay for single frequency MT by frequency alternation at low duty-cycle (FALDC); and, using variable flip angles (VFA) to increase SNR.

Approach: FALDC MT was compared to standard single frequency MT in simulations and brains at 3T. We compared 1.4-mm isotropic ihMT using FALDC MT and uniform versus VFA.

Results: No statistically significant difference was found between FALDC MT versus averaging images from positive and negative offset MT. IhMT SNR increased significantly for VFA data.

Impact: We demonstrate frequency alternating at low duty cycle MT and variable flip angle readouts significantly improve ihMT by reducing scan time and/or increasing resolution. These developments allow for easier clinical translation and will improve utility in neurological studies of myelin.

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