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Abstract #2026

IVIM-based virtual MR elastography for predicting fibrosis severity in rectal cancer: A comparison with conventional MR elastography

Yijing Luo1, Mengsi Li1, Wenguang Liu1, Huiting Zhang2, Yigang Pei1, and Wenzheng Li1
1Department of Radiology, Xiangya Hospital of Central South University, Changsha, China, 2MR Research Collaboration, Siemens Healthineers, Shanghai, China

Synopsis

Keywords: IVIM, Elastography, IVIM, virtual, rectal cancer, fibrosis

Motivation: No imaging marker currently predicts neoadjuvant chemoradiotherapy efficacy in rectal cancer (RC).

Goal(s): To generate virtual magnetic resonance elastography (v-MRE) imaging in patients with RC, assess fibrosis, and compare it with real MRE.


Approach: Using intravoxel incoherent motion (IVIM) imaging–derived parameters—shear-wave speed (c) and loss angle (φ), —correlations with shift ADC (sADC) were determined by developing equations for virtual shear-wave speed (Vc) and virtual loss angle (Vφ) to evaluate RC fibrosis.

Results: The optimal b0 and 1500 s/mm² combination revealed strong correlations between c, φ, and sADC, supporting v-MRE as a feasible alternative to MRE for diagnosing fibrosis severity.

Impact: v-MRE is a reliable alternative to MRE in diagnosing the degree of fibrosis in RC, which may assist clinicians in developing neoadjuvant therapeutic strategies for RC.

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