Keywords: IVIM, Diffusion Acquisition, Body, Liver, Kidney, Quantitative Imaging, Perfusion, Velocity & Flow, Precision & Accuracy, Validation
Motivation: Characterizing the dependencies of the first-order motion moment (M1) and encoding duration (T) on the intravoxel incoherent motion (IVIM) signal is important for developing accurate biophysical modeling and reproducible quantitative IVIM methods.
Goal(s): Evaluate the dependency of M1 and T on the IVIM signal in the liver and kidneys using specially designed gradient waveforms.
Approach: IVIM data with 85 unique b-M1-T-TE combinations were acquired in six healthy volunteers. Dependencies of the IVIM signal were evaluated using mixed-effects modeling.
Results: In the liver and kidneys, the IVIM signal demonstrated significant dependency on M1 (p<0.001) and non-significant dependency on T (p≥0.26).
Impact: In the liver and kidneys, a combined ballistic and pseudo-diffusion IVIM signal model with b and M1 dependence may be valid. IVIM models that depend on T may be inaccurate in these organs for T approximately 11.5-80.5ms.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords