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Abstract #2027

Dependency of the IVIM Signal on the First-Order Motion Moment and Encoding Duration in the Liver and Kidneys

Gregory Simchick1 and Diego Hernando1,2
1Radiology, University of Wisconsin-Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: IVIM, Diffusion Acquisition, Body, Liver, Kidney, Quantitative Imaging, Perfusion, Velocity & Flow, Precision & Accuracy, Validation

Motivation: Characterizing the dependencies of the first-order motion moment (M1) and encoding duration (T) on the intravoxel incoherent motion (IVIM) signal is important for developing accurate biophysical modeling and reproducible quantitative IVIM methods.

Goal(s): Evaluate the dependency of M1 and T on the IVIM signal in the liver and kidneys using specially designed gradient waveforms.

Approach: IVIM data with 85 unique b-M1-T-TE combinations were acquired in six healthy volunteers. Dependencies of the IVIM signal were evaluated using mixed-effects modeling.

Results: In the liver and kidneys, the IVIM signal demonstrated significant dependency on M1 (p<0.001) and non-significant dependency on T (p≥0.26).

Impact: In the liver and kidneys, a combined ballistic and pseudo-diffusion IVIM signal model with b and M1 dependence may be valid. IVIM models that depend on T may be inaccurate in these organs for T approximately 11.5-80.5ms.

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