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Abstract #2083

Metabolic Imaging of Hyperpolarized [1-13C]Pyruvate in a Ferret Model of Traumatic Brain Injury

Dirk Mayer1, Abubakr Eldirdiri1, Amanda L. Hrdlick2, Boris Piskoun2, Joshua C. Rogers1, Aditya Jhajharia1, Minjie Zhu1, Julie L. Proctor2, Ulrich H. Leiste3, William L. Fourney3, Jody C. Cantu4, Gary Fiskum2, and Molly J. Goodfellow2
1Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, United States, 3Aerospace Engineering, University of Maryland School of Engineering, College Park, MD, United States, 4Air Force Research Laboratory, 711th Human Performance Wing, Air and Space Biosciences Division, En Route Care Section, US Air Force Materiel Command, Baltimore, MD, United States

Synopsis

Keywords: Traumatic Brain Injury, Hyperpolarized MR (Non-Gas), Ferret

Motivation: Traumatic brain injury (TBI) represents a huge personal and economic burden. However, treatments and screening tools successfully developed in preclinical TBI models have failed to translate to the clinic.

Goal(s): To noninvasively measure brain energy metabolism after injury in a ferret model of TBI as ferrets possess primate-like gyrencephalic brains that may better replicate the human response to neurologic injury.

Approach: Metabolic imaging of hyperpolarized (HP) [1-13C]pyruvate and its conversion to lactate (Lac) and bicarbonate (Bic) was used in ferrets before and after injury.

Results: Reduced Bic/Pyr, reflecting reduced PDH activity, was detected 8-10 days post-injury whereas no difference in Lac/Pyr was observed.

Impact: Metabolic imaging of HP [1-13C]pyruvate for the noninvasive investigation of perturbations in brain energy metabolism in a highly translatable animal model of TBI may contribute to both improved understanding of injury mechanisms and more effective drug development.

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Abstract

Keywords