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Abstract #2084

Long-Term Benefits of Ketogenic/Modified Atkins Diet Following Moderate-Severe Traumatic Brain Injury.

Brenda Bartnik Olson1, Rhideeta Jalal2, Maria Recio3, Margie Carson4, Khongmany Wells4, Kyrstle Salvador3, and Duc Tran3
1Radiology, Loma Linda University Medical Center, Loma Linda, CA, United States, 2Psychology, Loma Linda University, Loma Linda, CA, United States, 3Physical Medicine and Rehabilitation, Loma Linda University Medical Center, Loma Linda, CA, United States, 4Nutrition and Dietetics, Loma Linda University, Loma Linda, CA, United States

Synopsis

Keywords: Traumatic Brain Injury, Spectroscopy, Traumatic Brain Injury

Motivation: Traumatic brain injury (TBI) increases the risk for neurodegenerative diseases like Alzheimer’s disease and chronic traumatic encephalopathy (CTE)1.

Goal(s): The goal of this study is to investigate the therapeutic potential of a ketogenic diet (KD)/modified Atkin’s diet (MAD) in moderate-severe TBI patients when given during inpatient rehabilitation.

Approach: We used ¹H-MRS and structural T1 weighted MRI to quantify the effects of short-term KD/MAD therapy on brain metabolism and volume.

Results: Our results demonstrate improved neuronal metabolism and reduced regional brain atrophy at 6 months suggesting the benefits of KD/MAD outlast the duration of the diet.

Impact: This study provides a first look at the effect of short-term KD/MAD on brain structure and metabolism following moderate-severe TBI, showing that its effects outlast the duration of the diet.

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