Abstract #2085

Investigating total sodium concentration in brain regions after concussion using anatomically-guided reconstruction

Alaleh Alivar^1,2, Georg Schramm³, Yongxian Qian^1,2, Mary Bruno^1,2, Fernando Boada⁴, and Yvonne W. Lui^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁴Radiological Sciences Laboratory, Stanford University, School of Medicine, Stanford, CA, United States

Synopsis

Keywords: Traumatic Brain Injury, Traumatic brain injury, Sodium MRI, Anatomical priors, Total Sodium Concentration

Motivation: Sodium (²³Na) MRI uniquely assesses sodium ionic homeostasis, potentially revealing brain sodium changes linked to mild traumatic brain injury (mTBI) and ionic dysfunction.

Goal(s): To show feasibility of whole brain and regional quantification of brain total sodium concentration (TSC) after injury in mTBI patients and measure regional TSC in a small cohort.

Approach: Using a novel anatomically-guided sodium reconstruction method, we quantified regional TSC in 11 patients with subacute mTBI.

Results: Our preliminary findings show no significant differences in in-vivo TSC between mTBI patients and controls. However, a trend toward higher TSC in certain corpus callosum regions was observed, lacking statistical significance.

Impact: We demonstrate feasibility of measuring and mapping regional brain sodium in a small cohort of mTBI subjects, providing a method by which to measure regional brain sodium and study potential ionic dysfunction after injury.

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