Abstract #2086

MRI Radiomics Features Correlates of Overall Survival in H3K27M Mutant Pediatric Diffuse Midline Gliomas

Melisa Özakçakaya¹, Nazmiye Tuğay Güven¹, Gökçe Hale Hatay², Esra Sümer-Arpak¹, Ayca Ersen-Danyeli^3,4, Memet Özek⁵, Bahattin Tanrıkulu⁵, Alp Dinçer^4,6,7, and Esin Ozturk- Isik^1,4

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Siemens Healthineers, Istanbul, Turkey, ³Department of Medical Pathology, Acıbadem University, Istanbul, Turkey, ⁴Brain Tumor Research Group, Acıbadem University, Istanbul, Turkey, ⁵Department of Pediatric Neurosurgery, Acıbadem University, Istanbul, Turkey, ⁶Department of Radiology, Acıbadem University, Istanbul, Turkey, ⁷Neuroradiology Application and Research Center, Istanbul, Turkey

Synopsis

Keywords: Cancer, Cancer

Motivation: There is a need to noninvasively identify overall survival (OS) correlates in H3K27M-mutant pediatric diffuse midline gliomas (DMGs) for improved prediction of prognosis.

Goal(s): To identify MRI radiomics feature correlates of OS in the H3K27M-mutant pediatric DMGs.

Approach: Radiomics features were extracted from T2-weighted MRI. The effects of tumor location, presence of contrast enhancement and/or necrosis, and radiomic features on OS of H3K27M-mutant DMGs were analyzed using Kaplan-Meier and Cox regression analysis.

Results: Tumors with high entropy, non-uniform patterns, and frequent intensity changes were correlated with shorter OS, alongside with pons localization, contrast enhancement, and necrosis.

Impact: Several radiomics features indicating heterogeneous tumor texture, presence of contrast enhancement and/or necrosis and pons localization were associated with shorter overall survival in H3K27M-mutant pediatric diffuse midline gliomas, which might potentially aid in treatment planning and patient prognosis improvement.

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