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Abstract #2094

Diffusion Tensor Imaging for Evaluating Glymphatic System Function in Neonates with Complex Congenital Heart Disease

María Guadalupe Mora Álvarez1, Josepheen De Asis-Cruz1, Kushal Kapse1, Gilbert Vezina1, Mary T Donofrio1, and Catherine Limperopoulos1
1Children's National Hospital, Washington, DC, United States

Synopsis

Keywords: Neuro, Neonatal, DTI-ALPS, CHD

Motivation: Given the strong link between cardiovascular and glymphatic systems, we investigated the DTI-ALPS index, a non-invasive measure of perivascular diffusion, as a biomarker of neurodevelopment in neonates with complex congenital heart disease (CHD).

Goal(s): To measure the DTI-ALPS index in healthy neonates and neonates with complex CHD before and after surgery.

Approach: We calculated the DTI-ALPS index, adjusting for gestational age at birth, in 182 healthy newborns and 120 CHD cases with pre- and post-operative DTI scans.


Results: CHD neonates demonstrated a lower DTI-ALPS index than controls. Interestingly, cases with transposition of the great arteries (TGA) showed further reduction of DTI-ALPS index post-surgery.


Impact: Assessing glymphatic system function (GSF) in newborns is challenging due to the need for contrast agents. However, this study demonstrates that the DTI-ALPs index holds promise as a non-invasive biomarker for GSF in high-risk neonates such as those with CHD.

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