Abstract #2099

Functional and structural effects of repetitive transcranial magnetic stimulation for the treatment of adolescent depression

Ping Wang^1,2, Lei Sun^2,3, Yingxue Gao², Ruohan Feng⁴, Hongwei Li⁴, Xinqin Ouyang⁴, and Xiaoqi Huang^2,5,6

¹West China Hospital, Sichuan University, Chengdu, China, ²Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu, China, ³Mianyang 404 Hospital, Mianyang, China, ⁴The Third People's Hospital of Mianyang, Mianyang, China, ⁵Research Unit of Psychoradiology, Chinese Academy of Medical Science, Chengdu, China, ⁶The Xiamen Key Lab of Psychoradiology and Neuromodulation, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: Adolescents, Adolescents, Depression; fMRI; DTI

Motivation: Depression in adolescents is a significant mental health concern, and while transcranial magnetic stimulation (TMS) has shown promise, its impact on brain structure and function in this population remains poorly understood.

Goal(s): To investigate the brain structural and functional changes after TMS treatment in adolescent depression.

Approach: Diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) data were collected to assess alterations in white matter structure and cortical intrinsic connectivity before and after TMS treatment.

Results: Preliminary findings suggest that stable white matter structure, with significant changes in functional connectivity, offering valuable insights for treatment strategies.

Impact: We identified brain regions potentially associated with the therapeutic effects of TMS in adolescent depression, which could potentially may inform more precise and targeted interventions.

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