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Abstract #2129

Diagnostic Value of IVIM-Based Virtual MR Elastography Compared with Real MR Elastography in Breast Lesions

Nan Zhou1, Jun Li1, Meining Chen2, Yanxin Zhou1, Yongmiao Wang1, Zhiquan Han1, Wanting Wang1, and Yueluan Jiang2
1Medical imaging department,First Affiliated Hospital of Kunming Medical University, Kunming, China, 2MR Research Collaboration, Siemens Healthineers Ltd, Chengdu, China

Synopsis

Keywords: Breast, IVIM, vMRE,rMRE

Motivation: Real magnetic resonance elastography (rMRE) assesses breast tissue stiffness but has limited accessibility due to hardware demands and patient tolerance issues. IVIM-based virtual MR elastography (vMRE) could offer a feasible alternative.

Goal(s): This study evaluates whether vMRE can differentiate normal, benign, and malignant breast lesions, potentially replacing rMRE in clinical use.

Approach: In 21 patients with breast lesions and 5 healthy controls, diagnostic performance was assessed with rMRE and vMRE, optimizing b-value combinations for virtual shear-wave speed (Cv-MRE).

Results: The optimal b-value pair (200 and 1500 sec/mm2 )enabled Cv-MRE to distinguish malignant from benign lesions, achieving high diagnostic accuracy (AUC=0.929) .

Impact: IVIM-based vMRE shows potential as a non-invasive alternative to rMRE for breast lesion diagnosis, offering broader applicability in patient care by enhancing diagnostic accessibility, especially for cases unsuited to traditional rMRE.

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