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Abstract #2134

Quantitative MRI in twin-to-twin transfusion syndrome reveals heterogeneity of placental perfusion

Erin K Englund1, Alex J Barker1,2, David M Mirsky1, Nicholas J Behrendt3, and Mariana L Meyers1
1Radiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States, 2Bioengineering, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States, 3Obstetrics and Gynecology, Maternal-Fetal Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, United States

Synopsis

Keywords: Placenta, Placenta, Twin-to-twin transfusion syndrome, IVIM, T2*

Motivation: Twin-to-twin transfusion syndrome (TTTS) is a potential complication in monochorionic twin pregnancies due to uneven blood flow between the twins.

Goal(s): To evaluate the placenta in TTTS and to compare blood flow (via IVIM) and relative oxygenation (via T2* mapping) between donor and recipient placental regions.

Approach: Anatomical and functional placental imaging was performed at 1.5T. A radiologist evaluated the presence of anatomical abnormalities, and quantitative comparisons of IVIM and T2* in periumbilical donor and recipient placental regions were performed.

Results: IVIM showed differences in D* between the donor and recipient placental regions, implying heterogeneous blood flow.

Impact: Qualitative and quantitative MRI of the placenta may provide insight into pathologic changes secondary to twin-to-twin transfusion syndrome. Differences in D* may imply variations in microvascular flow in the donor versus recipient placental regions.

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Keywords