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Abstract #2135

Comprehensive and individualised placental MRI for assessing placental development in health and disease

Daniel Cromb1, Jordina Aviles Verdera1, Megan Hall1, Anthony Price1,2, Joseph V Hajnal1, Mary Rutherford1, Lisa Story1,3, Serena J Counsell1, and Jana Hutter1,4
1Early Life Imaging Research Department, King's College London, London, United Kingdom, 2Medical Physics Department, GSTT NHS Trust, London, United Kingdom, 3Department of Women's and Children's Health, King's College London, London, United Kingdom, 4Smart Imaging Lab, University Hospital Erlangen, Erlangen, Germany

Synopsis

Keywords: Placenta, Placenta

Motivation: The placenta is crucial for fetal growth. MRI enables in-utero assessment of typical and atypical placental development, helping to understand mechanisms behind pathological conditions.

Goal(s): To combine placental diffusion-relaxation MRI with normative modelling to perform comprehensive individualised analyses of normal and altered placental development.

Approach: Combined T2*-diffusion placental data was acquired in 182 pregnant participants between 15-40 weeks gestation. Normative modelling was used to quantify deviations from normal in measures of placental function and structure in heterogeneous clinical cohorts.

Results: Significant differences in placental T2*, ADC and texture were seen between cases and controls, with altered placental development seen in all clinical cohorts.

Impact: Combining placental MRI data in large cohorts of healthy pregnant participants with normative modelling allows individualised assessments of placental structure and function to be performed, with the potential to help assess and understand when placental development is altered.

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