Keywords: Diffusion Acquisition, Diffusion Acquisition
Motivation: OGSE diffusion MRI (OGSE-dMRI) has been shown to differentiate tumor cellular density and thus improve tumor grading and post-treatment evaluation. Imaging protocol to maximize the differentiation is desired.
Goal(s): A framework to optimize OGSE-dMRI protocol.
Approach: Maximum b-values at different OGSE frequencies and echo times were generated based on gradient performance. ADC(f)/ADC(0 Hz) estimated from a tumor signal model was calculated. Receiver operating characteristic of differentiating cellular density was analyzed and the optimized protocol was obtained at maximum area-under-the-curve.
Results: Higher area-under-the-curve was achieved at high OGSE frequency, high b-value, and short echo time using high-performance gradient MRI system.
Impact: Radiologists, MR physicists, and engineers who need optimized imaging protocol of OGSE time-dependent diffusion MRI to assess tumor microstructure and improve clinical diagnosis of tumor grading and evaluation of treatment effectiveness.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords