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Abstract #2171

Oscillating Gradient Diffusion-Weighted MRI For the Assessment of Breast Lesions

Wenjie Tang1, Yuan Guo1, Zhidan Zhong1, Xiangdong Xu1, Yongxin Chen1, Yongzhou Xu2, and Xinhua Wei1
1Guangzhou First People’s Hospital, Guangzhou, China, 2Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Diffusion Analysis & Visualization, Breast

Motivation: Oscillating gradient diffusion-weighted imaging (OG-DWI) offers advanced microstructural insights, capturing cell density, diameter, and intracellular volume fraction, metrics often inaccessible with conventional MRI.

Goal(s): This study aimed to evaluate OG-DWI’s utility in quantitatively distinguishing breast lesions.

Approach: Using OG-DWI, we effectively differentiated benign from malignant lesions, particularly at lower ADC percentiles.

Results: These results suggest OG-DWI as a promising noninvasive imaging biomarker, enabling more accurate assessment of breast cancer aggressiveness by highlighting subtle microstructural differences linked to malignancy, thus enhancing diagnostic specificity.

Impact: Oscillating gradient DWI, with shorter diffusion times, complements conventional pulsed gradient DWI by revealing additional tumor microstructural details. Combined OGSE and PGSE sequences may enable novel diffusion-based biomarkers for improved breast lesion characterization and stratification.

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