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Abstract #2174

The Application of Time-Dependent Diffusion MRI in Clinical Staging and Pathological Differentiation of Cervical Squamous Carcinoma

Jun jun Li1, Yi Xiao1, Kai Ai2, Yi Zhu3, Yanhui Hao1, and Jianxin Guo1
1The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, 2Philips Healthcare, Xi’an, China, 3Philips Healthcare, Beijing, China

Synopsis

Keywords: Microstructure, Pelvis, Cervical Cancer;Time-dependent diffusion magnetic resonance imaging

Motivation: Time-dependent diffusion magnetic resonance imaging (TDD-MRI) remains underexplored in the clinical staging and differentiation of cervical squamous carcinoma (CSC).

Goal(s): To compare the diagnostic accuracy of TDD-MRI microstructural parameters with conventional apparent diffusion coefficient (ADC) values in the staging and differentiation of CSC.

Approach: TDD-MRI derived microstructural parameters-cell diameter (d), intracellular volume frac-tion (vin), extracellular diffusion coefficient (Dex), and ADC values were measured. Early-stage and mid-to-late-stage groups, poorly differentiated and moderately to well-differentiated groups were divided and compared.

Results: TDD-MRI parameters outperformed ADC in differentiating CSC. Combined TDD-MRI and ADC values achieved an AUC of 0.85, showing a significant improvement over ADC alone.

Impact: TDD-MRI parameters, particularly cell diameter, demonstrate superior accuracy to ADC in differentiating pathological grades and stages in CSC, supporting their use for non-invasive cervical cancer assessment.

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