Keywords: Microstructure, Diffusion Analysis and Visualization
Motivation: The potential of cellular microstructural information detected by the IMPULSED (imaging microstructural parameters using limited spectrally edited diffusion) MRI for evaluation of bone tumors has not been explored.
Goal(s): To assess the effectiveness of microstructural mapping by IMPULSED MRI in distinguishing between malignant and benign bone tumors.
Approach: This prospective study included 29 patients of bone tumors. The microstructural parameters were fitted with a two-compartment model to estimate mean cell diameter, intracellular volume fraction, extracellular diffusivity and cellularity.
Results: Intracellular volume fraction and cellularity show potential diagnostic values in differentiating benign and malignant bone tumors.
Impact: This study revealed the changes in quantitative microstructural mapping across the spectrum of bone tumors. Intracellular volume fraction and cellularity are potential markers for differentiating benign and malignant bone tumors.
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