Keywords: MR-Guided Focused Ultrasound, Brain
Motivation: The relationship between blood-brain barrier opening (BBBO) observed in contrast-enhanced MRI and the real-time cavitation dose measured during low-intensity focused ultrasound treatment (LIFU) is not fully understood.
Goal(s): The aim was to identify the relationship between MRI-derived metrics and real-time cavitation dose measured by hydrophones.
Approach: Cavitation dose and semi-quantitative MRI derived metrics from 28 putamen openings in patients with Parkinson’s disease (PDD) were analyzed.
Results: The cavitation dose correlated strongly with semi-quantitative metrics, indicating a reliable relationship between cavitation parameters and BBBO. Additionally, a positive but weaker correlation was observed between cavitation dose and hypointensities (damage) in SWI images.
Impact: This study highlights a promising relationship between MRI-derived metrics and real-time cavitation dose measured by hydrophones during LIFU. This insight could enable dynamic adjustments during treatment, improving BBBO monitoring and potentially enhancing treatment efficacy and safety.
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