Abstract #2183

An Improved 3D Stack-of-Spirals Sequence for Simultaneous Brain and Skull Thermometry in Clinical Transcranial MRgFUS Surgery

Sheng Chen¹, Steven P. Allen², John P. Mugler III³, W. Jeffrey Elias⁴, G. Wilson Miller³, and Craig H. Meyer^1,3

¹Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ²Electrical and Computer Engineering, Brigham Young University, Provo, UT, United States, ³Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, ⁴Department of Neurological Surgery, University of Virginia, Charlottesville, VA, United States

Synopsis

Keywords: MR-Guided Focused Ultrasound, MR-Guided Interventions, MRgFUS

Motivation: Monitoring off-target heating of the skull and soft tissue during transcranial MRgFUS surgery is necessary. However, both T1- and PRF-based thermometry with the previously proposed sequence may be biased in clinical settings.

Goal(s): To improve the accuracy of both T1 mapping in cortical bone and PRF temperature measurement in soft tissue.

Approach: An improved 3D stack-of-spirals sequence was implemented featuring fat suppression, variable UTE, and a retraced spiral-in-and-out readout with fixed later TE. The sequence was tested in both phantom and human studies in a clinical setting.

Results: Improved accuracy of T1 and temperature maps were demonstrated.

Impact: The proposed sequence that features fat suppression, variable UTE, and a retraced-spiral-in-and-out trajectory should improve accuracy in simultaneous brain (PRF-based) and skull (T1-based) thermometry in a clinical setting and is promising in monitoring unintended heating during clinical transcranial MRgFUS surgery.

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