Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound, Blood Brain barrier
Motivation: There is a lack of comprehensive MRI-based evaluation of low-intensity focused ultrasound (LIFU)-induced blood-brain barrier (BBB) opening in rat models.
Goal(s): We aim to develop a safe BBB opening protocol in rat models with jugular vein catheter, using cavitation monitoring and MRI assessment.
Approach: We investigated the effects of sonication parameters on BBB opening and tissue damage and the relationship between ultrasound cavitation measures and contrast changes on post-treatment MRI (T1W, T2W, SWI, T2*)
Results: Optimal BBB opening was achieved at 0.45 MPa with 10 ms burst length and continuous microbubble injection, confirmed by T1-weighted MRI showing hyperintensity and no brain damage.
Impact: The optimized BBB opening and monitoring protocol developed in this study will enable preclinical studies of delivery of the therapeutic compounds across the BBB.
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