Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound
Motivation: Focused ultrasound (FUS) with microbubbles is a promising technology for opening the blood-brain barrier (BBB) to deliver therapeutics to the brain. Answering fundamental questions about the process of BBB opening will aid in the translation of this method to the clinic.
Goal(s): Use FUS, 2-photon microscopy, MRI and immunohistochemistry to investigate FUS-induced changes in wild type and 5X-FAD AD mice.
Approach: A cross-sectional study involving MRI, 2PM, and IHC to examine BBB opening at multiple timepoints in a disease model.
Results: Results suggest BBB opening occurs in capillaries and that the BBB opening is similar between WT and 5X-FAD mice.
Impact: DCE imaging and sub-micron imaging of the microvasculature after BBB opening provide insight into which vessels are opened after FUS and improve pharmacokinetic understanding of the paravascular space in an Alzheimer’s Disease model.
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