Abstract #2199

Technical Development and In Silico Implementation of SyntheticMR in Adaptive Radiation Therapy on the 1.5T MR-Linac

Lucas McCullum^1,2, Samuel Mulder^1,2, Natalie West^1,2, Robert Aghoghovbia³, Alaa Mohamed Shawky Ali¹, Hayden Scott^1,2, Travis Salzillo⁴, Yao Ding⁴, Alex Dresner⁵, Ergys Subashi⁴, Dan Ma⁶, R. Jason Stafford⁷, Ken-Pin Hwang⁷, and Clifton D. Fuller¹

¹Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ²UT MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, United States, ³Morehouse School of Medicine, Atlanta, GA, United States, ⁴Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵Philips Healthcare MR Oncology, Cleveland, OH, United States, ⁶Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁷Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: MR-Guided Radiotherapy, MR-Guided Radiotherapy, Synthetic MR, Quantitative MRI

Motivation: SyntheticMR has not been studied on the 1.5T MR-Linac despite its potential value for treatment adaptation based on quantitative imaging.

Goal(s): The goal of this study was to investigate the technical feasibility of translating SyntheticMR to the 1.5T MR-Linac for the radiation therapy workflow.

Approach: SyntheticMR was scanned on phantoms and a volunteer and analyzed for geometric distortion and quantitative T1, T2, and PD vial measurements against reference values.

Results: There was no significant geometric distortion. Mean bias was below 3% for T1, 13% for T2, and 3% for PD vials and the Lin's Concordance Correlation Coefficient was above 0.96 across all vials.

Impact: SyntheticMR can enhance the MR-Linac workflow in the following ways: 1) multi-contrast anatomic/quantitative information in a single scan, 2) superior quantitative accuracy and spatial resolution compared to existing techniques, and 3) clinically acceptable repeatability, reproducibility, and spatial accuracy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.