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Abstract #2203

Real-Time MR-Based Measurement of Radiation-Induced Free Radical Generation on Clinical Low-Field 0.35T MR-Linac

Claire Keun Sun Park1, Noah Warner1,2, Veena Venkatachalam1, and Atchar Sudhyadhom1
1Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 2Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA, United States

Synopsis

Keywords: MR-Guided Radiotherapy, Treatment Response

Motivation: Current radiation therapy dosing regimens lack precision to account for spatial- or patient-specific variations in biological responses, leading to suboptimal therapeutic outcomes. A real-time, non-invasive method to monitor radiation-induced free radical generation (FRG) and molecular damage could enable more precise, biologically-tailored treatments.

Goal(s): To develop a non-invasive framework for real-time MR-based quantification of radiation-induced FRG.

Approach: We developed an MP2RAGE-based T1 mapping protocol on a clinical 0.35T MR-Linac to measure temporal dynamics of radiation-induced FRG during simultaneous irradiation of biologically-relevant chemical phantoms.

Results: We demonstrated measurable T1 changes due to superoxide radical production, providing the first quantification of real-time FRG during irradiation.

Impact: This work establishes the foundation for real-time, non-invasive measurement and monitoring of radiation-induced free radical generation (FRG) during radiation therapy, toward enabling biological adaption that accounts for spatial- and patient-specific responses, and ultimately improving therapeutic outcomes.

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