Keywords: Psychiatric Disorders, fMRI (resting state), major depressive disorder, anterior cingulate cortex subregions, acute status, remitted status, resting-state functional connectivity
Motivation: The anterior cingulate cortex (ACC) subregional functional connectivity alterations from acute to remitted status of major depressive disorder (MDD) remained unclear.
Goal(s): To explore the status-related alterations (acute vs. remitted status) in functional connectivity of ACC subregional networks in patients with MDD.
Approach: We performed a longitudinal study to investigated ACC subregional functional connectivity alteration from acute to remitted status, and their correlations with clinical symptoms changes in MDD patients.
Results: We discovered perigenual/subgenual ACC-based hypoconnectivity and cadual ACC-based hyperconnectivity with default mode network related to the remission period of MDD, and decreased ACC subregional connectivity alterations were correlated with depression symptom improvement.
Impact: Our findings highlight the status-related alterations in rsFC of ACC subregional networks in MDD, which can help to understand the neurobiological mechanisms of depression at various stages and provide theoretical guidance for clinical management.
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