Meeting Banner
Abstract #2230

State-related alterations of anterior cingulate cortex subregional connectivity in major depressive disorder

Hanbing Shao1, Zilin Zhou1, Lianqing Zhang1, Yingxue Gao1, Hailong Li1, Xinyue Hu1, Lingxiao Cao1, Weijie Bao1, Mengyue Tang1, Yidan Wang1, Qiyong Gong1,2,3, and Xiaoqi Huang1,2,3
1Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, 2Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, 3The Xiamen Key Lab of Psychoradiology and Neuromodulation, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: Psychiatric Disorders, fMRI (resting state), major depressive disorder, anterior cingulate cortex subregions, acute status, remitted status, resting-state functional connectivity

Motivation: The anterior cingulate cortex (ACC) subregional functional connectivity alterations from acute to remitted status of major depressive disorder (MDD) remained unclear.

Goal(s): To explore the status-related alterations (acute vs. remitted status) in functional connectivity of ACC subregional networks in patients with MDD.

Approach: We performed a longitudinal study to investigated ACC subregional functional connectivity alteration from acute to remitted status, and their correlations with clinical symptoms changes in MDD patients.

Results: We discovered perigenual/subgenual ACC-based hypoconnectivity and cadual ACC-based hyperconnectivity with default mode network related to the remission period of MDD, and decreased ACC subregional connectivity alterations were correlated with depression symptom improvement.

Impact: Our findings highlight the status-related alterations in rsFC of ACC subregional networks in MDD, which can help to understand the neurobiological mechanisms of depression at various stages and provide theoretical guidance for clinical management.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords