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Abstract #2234

Altered neurovascular coupling in drug-naïve first-episode major depressive disorder patients

Shuyang Cai1, Xiumei Wu2, Qinger Guo1, Yu Fang1, Yafei Zhang1, Yating Lv3, and Hong Yang1
1The First Affiliated Hospital, College of Medicine, Zhejiang University, hangzhou, China, 2University of Electronic Science and Technology of China, chengdu, China, 3Centre for Cognition and Brain Disorder, The Affiliated Hospital of Hangzhou Normal University, hangzhou, China

Synopsis

Keywords: Psychiatric Disorders, Arterial spin labelling, Major depressive disorder

Motivation: Explore the pathophysiological mechanisms of major depressive disorder (MDD) from the perspective of neurovascular coupling (NVC).

Goal(s): Investigate the alteration of NVC in MDD patients and the effects of symptom severity and gender on NVC.

Approach: The spatial and temporal correlations between amplitude of low frequency fluctuation (ALFF) and cerebral blood flow (CBF) were analyzed as NVC metrics.

Results: (1) Compared with HCs, MDD patients exhibited decreased global ALFF-CBF coupling, and decreased coupling was prominent in patients with severe depression and female patients. (2) Patients demonstrated altered regional ALFF-CBF coupling in limbic system, default mode network (DMN), visual network and frontal cortex.

Impact: Our findings suggest the NVC decoupling may be a potential pathophysiological mechanism in MDD and provide insights into understanding its relationships to both disease severity and gender. In summary, the neurovascular decoupling may represent a biological marker in MDD.

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