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Abstract #2235

CEST MRI of Regional Molecular Changes in the Brain for Depression Assessment

Joseph H.C. Lai1, Canghao Sun1, Yang Liu2,3, Shulan Qiu1, Weixiong Zhang1, Jing Cai1, and Tian Li1
1Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, Hong Kong, 2Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 3Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, Hong Kong

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, Depression

Motivation: Revealing molecular alterations in the brain can provide a better assessment of depression and can benefit treatment planning.

Goal(s): Our findings would serve as potential biomarkers for the assessment of depression.

Approach: Here we applied CEST to study the regional brain changes in a depression model.

Results: CEST, with multi-parametric readout, showed significant changes at the cortex and thalamus, which attributed to the alterations in molecular content and the exchange rate (P<0.05). Additionally, we observed that female mice tended to have higher CEST signals than male mice in the hippocampus and thalamus under depression (P<0.05).

Impact: The molecular findings here can provide valuable information for the development of CEST in psychiatry. CEST is non-invasive and non-contrast-enhanced, which can be translated to the clinical level for better diagnosis and treatment planning for depression.

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