Keywords: Psychiatric Disorders, Psychiatric Disorders, Depression
Motivation: Revealing molecular alterations in the brain can provide a better assessment of depression and can benefit treatment planning.
Goal(s): Our findings would serve as potential biomarkers for the assessment of depression.
Approach: Here we applied CEST to study the regional brain changes in a depression model.
Results: CEST, with multi-parametric readout, showed significant changes at the cortex and thalamus, which attributed to the alterations in molecular content and the exchange rate (P<0.05). Additionally, we observed that female mice tended to have higher CEST signals than male mice in the hippocampus and thalamus under depression (P<0.05).
Impact: The molecular findings here can provide valuable information for the development of CEST in psychiatry. CEST is non-invasive and non-contrast-enhanced, which can be translated to the clinical level for better diagnosis and treatment planning for depression.
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