Abstract #2242

Divergent effects of sex on structural covariance networks of thalamic nuclei in drug-naive patients with major depressive disorder

Yidan Wang¹, Xinyue Hu¹, Lianqing Zhang¹, Hailong Li¹, Yingxue Gao¹, Mengyue Tang¹, Weijie Bao¹, Zilin Zhou¹, Qiyong Gong^1,2,3, and Xiaoqi Huang^1,2,3

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Science, Chengdu, China, ³The Xiamen Key Lab of Psychoradiology and Neuromodulation, West China Xiamen Hospital of Sichuan University, Xiamen, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders

Motivation: Major depressive disorder (MDD) shows sex differences in terms of incidence and symptoms, but the neurobiological basis underlying these sex differences remains to be clarified.

Goal(s): To investigate sex differences in MDD and HC, focusing on the structural covariance networks (SCN) of thalamic nuclei.

Approach: We segmented thalamic nuclei and constructed a SCN using 3D T1 and DTI.

Results: SCN analysis in MDD patients showed reduced nodal degree in the right LGN and left LP nuclei in females. Betweenness centrality was lower in the left MV (Re), VA, and right VAmc, while both betweenness and closeness centrality increased in the right PuL.

Impact: The study highlights thalamic nuclei changes in MDD, revealing intrinsic thalamic nodal network alterations in females. Structural covariation pattern between thalamic nuclei may be an important marker of sex severity in MDD.

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