Abstract #2260

Prediction of long-term neurodevelopmental delay using cerebral oxygen extraction fraction in neonates with hypoxic ischemic encephalopathy

Peiying Liu¹, Fulden Aycan², Brenda T Hussey-Gardner², Dengrong Jiang³, Yezhi Pan⁴, Shuo Chen⁴, Eunsung Cho², and Dina El-Metwally²

¹Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States, ³Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neonatal, Neonatal, Neuro; Biomarkers; Oxygenation; Pediatrics

Motivation: About half of the neonates with Hypoxic-ischemic-encephalopathy (HIE) have poor long-term neurodevelopmental outcomes, so biomarkers predicting long-term outcomes are needed. Oxygen extraction fraction (OEF) in the brain is sensitive in detecting HIE abnormalities at the neonatal stage.

Goal(s): To evaluate if OEF can predict long-term neurodevelopment delay in neonates with HIE.

Approach: The global OEF was measured non-invasively by TRUST MRI in 14 neonates with HIE at 1 week old. Their neurodevelopmental status was assessed at 5-9 and 12-20 months, respectively.

Results: A significant association was observed between neonatal OEF and neurodevelopment status. Lower OEF was associated with delayed neurodevelopment after 12 months.

Impact: This study demonstrated that global OEF, measured by TRUST MRI non-invasively in 1.2 minutes, can be an effective biomarker for predicting long-term neurodevelopmental outcomes in neonates with HIE, assisting clinical decisions on early initiation of adequate therapies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.