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Abstract #2268

Visualization of Vasoactive Treatment by Hyperpolarized Xenon-129 MRSI and Cardiogenic Oscillations

Markus Phillip Andersen1, Mattias Hedegaard Kristensen1, Esben Søvsø Szocska Hansen1, Rolf F Schulte2, Mohsen Redda1, Uffe Kjærgaard1, Michael Væggemose1,3, and Christoffer Laustsen1
1MR Research Centre, Aarhus University, Aarhus N, Denmark, 2GE HealthCare, Munich, Germany, 3GE HealthCare, Brøndby, Denmark

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), Cardiovascular, heart, lung, animals, biology models methods, flow

Motivation: The invasive nature of cardiopulmonary hemodynamic assessments leaves a gap in accessibility of diagnostic tools in fragile chronically ill patients with pulmonary hypertension.

Goal(s): Understanding the complex interplay between hyperpolarized (HP) xenon-129 MRSI and cardiopulmonary hemodynamics, in non-invasive assessment of disease progression and treatment response.

Approach: Vasoactive interventions were conducted on seven pigs, comparing invasive cardiopulmonary measurements with HP xenon-129 MRSI dissolved-phase and cardiogenic oscillations.

Results: Interventions successfully caused vasoactive hemodynamic changes, detectable by HP 129Xe MRSI. An inverse proportional correlation was found between mPAP and oscillation amplitude, RBC AUC and RBC:mem.

Impact: Hyperpolarized 129Xe MRSI enables non-invasive monitoring of pulmonary hypertension, facilitating early diagnosis and precise hemodynamic assessment. This approach supports optimized treatment, reduces hospitalizations, and enhances quality of life and survival in chronically ill patients.

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Keywords