Keywords: Lung, Hyperpolarized MR (Gas), Hyperpolarized MR (Gas), Cardiovascular, heart, lung, animals, biology models methods, flow
Motivation: The invasive nature of cardiopulmonary hemodynamic assessments leaves a gap in accessibility of diagnostic tools in fragile chronically ill patients with pulmonary hypertension.
Goal(s): Understanding the complex interplay between hyperpolarized (HP) xenon-129 MRSI and cardiopulmonary hemodynamics, in non-invasive assessment of disease progression and treatment response.
Approach: Vasoactive interventions were conducted on seven pigs, comparing invasive cardiopulmonary measurements with HP xenon-129 MRSI dissolved-phase and cardiogenic oscillations.
Results: Interventions successfully caused vasoactive hemodynamic changes, detectable by HP 129Xe MRSI. An inverse proportional correlation was found between mPAP and oscillation amplitude, RBC AUC and RBC:mem.
Impact: Hyperpolarized 129Xe MRSI enables non-invasive monitoring of pulmonary hypertension, facilitating early diagnosis and precise hemodynamic assessment. This approach supports optimized treatment, reduces hospitalizations, and enhances quality of life and survival in chronically ill patients.
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