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Abstract #2288

Disease Detection Rate of Combination Ga-68 PSMA-PET/CT and Whole-Body MRI in Biochemical Recurrence After Prostatectomy

Sajeev Sridhar1, Pankaj Patel2, Zeyad Abouelfetouh1, Stephen Chiang3, Raj Satkunasivam4,5, Dharam Kaushik4, Michael Brooks4, Brian Miles4,5, Diego Martin1,2, Eleni Efstathiou6,7, and Nakul Gupta1,2,8
1Radiology, Houston Methodist Research Institute, Houston, TX, United States, 2Radiology, Houston Methodist Hospital, Houston, TX, United States, 3Radiology/Nuclear Medicine, Houston Methodist Hospital, Houston, TX, United States, 4Urology, Houston Methodist Hospital, Houston, TX, United States, 5Urology, Houston Methodist Research Institute, Houston, TX, United States, 6Medical Oncology, Houston Methodist Hospital, Houston, TX, United States, 7Medical Oncology, Houston Methodist Oncology Partners, Houston, TX, United States, 8Diagnostic Radiology, Houston Radiology Associated, Houston, TX, United States

Synopsis

Keywords: Prostate, Prostate, Prostate cancer, recurrence, Metastasis, PSMA, PET, CT, Whole body, MRI

Motivation: Varying imaging strategies are used in patients with biochemical recurrence (BCR) after prostatectomy. Timely detection facilitates early intervention and can direct therapy based upon type and location of recurrence.

Goal(s): To estimate the added contribution of Whole-Body MRI to PSMA-PET/CT in prostatectomy patients with BCR.

Approach: Retrospective analysis of n=48 PSMA-PET/CT and subsequent Whole-Body MRI scans in patients with BCR. Detection and type of recurrence were recorded for each modality as well as PSA values.

Results: WB-MRI significantly increased the disease detection rate compared to PSMA-PET/CT alone in cases of BCR from 29% to 52% overall (p=0.001).

Impact: Our work demonstrates the added value of MRI as an addition to PET/CT scans in the context of BCR, as well as some of the limitations of PET/CT alone. Further research needs to be done in a larger patient population.

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Keywords